- Title
- DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate
- Creator
- Maltby, Vicki E.; Lea, Rodney A.; Ribbons, Karen A.; Sanders, Katherine A.; Kennedy, Daniel; Min, Myintzu; Scott, Rodney J.; Lechner-Scott, Jeannette
- Relation
- Multiple Sclerosis Journal: Experimental, Translational and Clinical Vol. 4, Issue 3
- Publisher Link
- http://dx.doi.org/10.1177/2055217318787826
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2018
- Description
- Background: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. Objective: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis patients. Methods: We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4+ T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment. Results: Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site. Conclusion: This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.
- Subject
- multiple sclerosis; dimethyl fumarate; immunology; DNA methylation; relapsing-remitting; CD4+ T cells
- Identifier
- http://hdl.handle.net/1959.13/1446539
- Identifier
- uon:42900
- Identifier
- ISSN:2055-2173
- Language
- eng
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